CXCR2-positive neutrophils are essential for cuprizone-induced demyelination: relevance to multiple sclerosis
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چکیده
منابع مشابه
GAS6 Enhances Repair Following Cuprizone-Induced Demyelination
Growth arrest-specific protein 6 (gas6) activities are mediated through the Tyro3, Axl, and Mer family of receptor tyrosine kinases. Gas6 is expressed and secreted by a wide variety of cell types, including cells of the central nervous system (CNS). In this study, we tested the hypothesis that administration of recombinant human Gas6 (rhGas6) protein into the CNS improves recovery following cup...
متن کاملThe Cuprizone-Induced Experimental Demyelination – A Promising Animal Model for Multiple Sclerosis Type III-IV Ph.D. Thesis
sVeto S, Acs P, Bauer J, Lassmann H, Berente Z, Sumegi B, Komoly S, Gallyas F Jr,Illes Z, 2010. Inhibiting poly(ADP-ribose) polymerase: a potential therapy againstoligodendrocyte death in multiple sclerosis. Clinical Immunology 135: S30-S30 Veto S, Acs P, Bauer J, Lassmann H, Berente Z, Sumegi B, Komoly S, Gallyas F Jr,Illes Z, 2010. Poly(ADP-ribose) polymerase (PARP) is activat...
متن کاملCellular and molecular neuropathology of the cuprizone mouse model: Clinical relevance for multiple sclerosis
The cuprizone mouse model allows the investigation of the complex molecular mechanisms behind nonautoimmune-mediated demyelination and spontaneous remyelination. While it is generally accepted that oligodendrocytes are specifically vulnerable to cuprizone intoxication due to their high metabolic demands, a comprehensive overview of the etiology of cuprizone-induced pathology is still missing to...
متن کاملThe Effect of Aerobic Training with the Consumption of Probiotic on the Myelination of Nerve Fibers in Cuprizone-Induced Demyelination Mouse Model of Multiple Sclerosis
Introduction: Extensive human and animal research shows that exercise has beneficial effects on multiple clinical outcomes for patients suffering from multiple sclerosis (MS). This research was an attempt to address the effect of aerobic training with the consumption of probiotic on the myelination of nerve fibers in a cuprizone-induced demyelination mouse model of MS. Methods: Mice, which we...
متن کاملMyelin repair is accelerated by inactivating CXCR2 on nonhematopoietic cells.
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the CNS and remyelination in MS ultimately fails. Although strategies to promote myelin repair are eagerly sought, mechanisms underlying remyelination in vivo have been elusive. CXCR2 is expressed on neutrophils and oligodendrocyte lineage cells in the CNS. CXCR2-positive neutrophils facilitate inflammatory demyelination in dem...
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ژورنال
عنوان ژورنال: Nature Neuroscience
سال: 2010
ISSN: 1097-6256,1546-1726
DOI: 10.1038/nn.2491